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Masterjohn: The Sigma-1 receptor is still poorly understood in terms of its overall function, but we at least know that it appears to be involved in the stress response because it is necessary for the response to cortisol

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Mechanistically, DHA and EPA attenuate post-stroke neuroinflammation by suppressing pro-inflammatory cytokine production, inhibiting microglial overactivation, and promoting the biosynthesis of specialized pro-resolving lipid mediators such as resolvins, protectins, and maresins (142)

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