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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Wang Z, Bergeron N, Levison BS, Li XS, Chiu S, Jia X, Koeth RA, Wu Y, Tang WHW, Krauss RM, et al

Common mistake: taking L-carnitine alone on an empty stomach without any carbohydrates

A mixed-methods approach

References 1.Chun Y., Lee K., Kang S., Lee N., Kim J

Lipid acyl CoA is bound to carnitine by carnitine palmitoyltransferase I (CPT I) to form acyl carnitine

While you should have suspicion for this pathology in any patient presenting with altered mental status on valproic acid, the following factors may place the patient at an increased risk for this complication: Anticonvulsant polytherapy and medication interactions Medications such as topiramate, phenytoin, carbamazepine, and phenobarbital have been associated with increased ammonia levels when used in conjunction with valproic acid Renal failure Hepatic failure Carnitine deficiency: Carnitine assists with the elimination of valproic acid and minimizes the formation of harmful valproic acid metabolites
