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The mammalian target of rapamycin (mTOR) pathway is a central regulator of cellular growth, metabolism, and homeostasis, integrating a wide array of intracellular and extracellular cues, including nutrient availability, growth factors, and cellular stress, to coordinate anabolic and catabolic processes such as protein, lipid, and nucleotide synthesis

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This review highlights epidemiology, risk factors, genetics, pathogenesis, clinical manifestations, diagnostic methods, epigenetic mechanisms, and recent therapeutic advances.

Future studies should also consider the evaluation of epigenetic marks recently in the research spotlight such as DNA hydroxymethylation and the role of underlying genetic variants.

Research shows that glutathione can...