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However, small molecules such as cisplatin and aminoglycoside antibiotics can cross this barrier [27] This entry exposes hair cells to these ototoxic drugs, allowing them to enter the hair cells through their apical membrane, leading to ototoxic effects [28]

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For example, the enzyme that turns cysteine byproducts into sulfate in the glutathione pathway is called the sulfite oxidase (SUOX) enzyme

Guo Y, Wang M, Zou Y, Jin L, Zhao Z, Liu Q, et al

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