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Mechanistically, intranasally administered agents may be absorbed through the olfactory epithelium or trigeminal nerve endings and transported to the brain via extracellular diffusion and intracellular axonal pathways, which may partially bypass BBB-related constraints (Raghav et al., 2023

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Researchers should note minor and transient side effects that have been anecdotally reported: Headaches Drowsiness

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[DOI] [PubMed] [Google Scholar] 55.Dembinska-Kiec A., Pallapies D., Simmet T., Peskar B.M., Peskar B.A

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