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The key anti-oxidative transcription factor, nuclear factor E2 related factor 2 (Nrf2 or NFE2L2), plays a dominant role in defense machinery by reprogramming the iron, intermediate, and glutathione peroxidase 4 (GPX4)-related network and the antioxidant system to attenuate ferroptosis

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The rats were treated with GSH (250mg/kg, ig) or levodopa (L-dopa, 100mg/kg, ig) plus carbidopa (10mg/kg, ig)

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