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Safety and regulation are uncertain, with insufficient clinical data, potential adverse reactions, and unapproved regulatory status

doi: 10.1074/jbc.M703091200 88 FrancoR.SchoneveldO

Thyroid issues, such as risk of C-cell tumors, have been seen in animal studies (but not yet humans)

Those with diabetes, pernicious anemia and other diseases may benefit from methylcobalamin supplementation

it's problematic for high-dose NAD+, where individual tolerance, methylation status, and underlying health conditions significantly affect both safety and efficacy

Abouhussein DMN
