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The intracellular glutathione level, lactate dehydrogenase release, urea production and mitochondrial activity were also not affected by the modeling solution, proving that the cells in this three-dimensional model had complete functions

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However, a causal link is yet to be confirmed because this finding could be confounded by the presence of CLN6 disease

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[PubMed] [Google Scholar] 99.Horowitz M., Esakov E., Rose P., Reizes O

We thus tried to investigate the potential for VRK2 phosphorylating Sec24C and found that the phosphorylation level of Sec24C was attenuated in VRK2-KO cells but elevated when restoring the expression of VRK2 (Fig