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[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Obeid R

To overcome this, various techniques such as peptide cyclization, amino acid substitution with D-isomers, PEGylation, and encapsulation in carriers (e.g., nanoparticles, hydrogels) are being explored, though these approaches can increase complexity and production costs
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But it also explains why transition periods can look like worsening
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