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Furthermore, as activated immune cells, melanophages may communicate and stimulate dermal T lymphocytes and secrete proinflammatory cytokines, potentially sustaining the chronic status of the hyperpigmented lesion [157, 158]

To ensure consistency and accuracy in the imaging process, all images were acquired under identical field conditions

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This may be mitigated using a bispecific anti-EGFR x anti-CD3 utilising the EGF receptor for induction of T-cell-mediated cell killing 25

After scopolamine treatment, mice showed decreased expression patterns of cholinergic genes ( Chrnb3 , Chrnb4 , Chat , Camk2b , Slc18a3 , Chrm1 ) compared to the vehicle, although statistical significances were lacking