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For example, chronic cocaine exposure leads to D 1 supersensitivity in NAc (Nestler and Aghajanian, 1997), and increases in D 2 receptor antagonist binding sites in the DS and NAc (Goeders and Kuhar, 1987)

[DOI] [PubMed] [Google Scholar] 43.Zhong Q, Putt DA, Xu F, Lash LH

FEBS Lett 584:889897 Krylova VV, Dubrovo NP, Izmailov SF (2007) The effect of metabolites on the pH gradient and membrane potential of the bean peribacteroid membrane

108 GodboutJ

Thus, association of biomarkers with cannabinoid potency is limited to a range of concentrations arbitrarily determined and does not represent direct linear correlation

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