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There are Biological and practical considerations that influence the effect of glutathione, for instance
Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke

Authors thank Thomas Vanek (Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic) for the A

, & Roper, S

Mitochondrial pyruvate metabolism is regulated by many enzymes, including the recently discovered mitochondria pyruvate carrier, pyruvate dehydrogenase, and pyruvate carboxylase, to modulate overall pyruvate carbon flux
82 , E313E328 (2004)