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Cell 179 , 864879.e819 (2019)

c-Myc directly activates the genes involved in nucleotide synthesis, including thymidylate synthase for pyrimidine metabolism, inosine monophosphate dehydrogenase 1 and 2 for purine metabolism, and phosphoribosyl pyrophosphate (PRPP) synthetase 2 for the production of PRPP, which is a common precursor for purine and pyrimidine nucleotides

During a flare-up, symptoms may go beyond those that affect the digestive system, including: Rashes or patches of red, swollen skin

Once Cd induces BBB disruption and permeability increase, it can penetrate and accumulate in the CNS, thus leading to cerebral damage [131]

An overview, 2021

[5] Iyer KS, Marks GA, Kastin AJ, McCann SM