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Metformin causes a modest inhibition of mitochondrial respiratory chain Complex I, leading to a mild reduction in adenosine triphosphate (ATP) synthesis and a concomitant increase in adenosine monophosphate (AMP) cellular levels

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[DOI] [PMC free article] [PubMed] [Google Scholar] Kaczmarczyk, R
This defect may contribute to the development of EAR on the skin of infected patients
