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The safety record is generally placebo-like, but several specific findings deserve attention

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The failure of methionine synthesis due to cobalamin deficiency may either (1) lead to an accumulation of 5-methyl-tetrahydrofolate, trapping folate in a chemical form unusable in purine synthesis (the "folate trap" hypothesis) or (2) impair methylation reactions needed to produce formyl-tetrahydrofolate, a precursor to 5,10-methylene tetrahydrofolate

After being separated, the platelet-rich blood sometimes has 10 times a richer concentration of growth factors

Owing to the light-trapping microstructures (Supplementary Fig