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Additionally, MnO 2 functions as a GSH-depleting agent, as evidenced by the strongest green fluorescence (representing ROS) and significant disruption of the GSH/GSSG ratio observed in the Cu-Mn NPs group ( Figure 6K-L )

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GR depends on sufficient NADPH availability

Toxicol.,2003, 16, 1652-1660 24

They identified that SUMOylation of CD45 reduced its phosphatase activity, consequently enhancing STAT3 activation and contributing to the immunosuppressive nature of MDSCs [155]