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Given the similarity in resource use between this subset of cases and cases in MS-DRGs 799, 800, and 801, and that we believe that procedure codes describing the occlusion of the splenic artery are related to principal diagnoses in MDC 16 (typically major laceration of spleen, initial encounter), these cases would be more appropriately assigned to MS-DRGs 799, 800, and 801 in MDC 16 than their current assignment in MS-DRGs 987 through 989

doi: 10.1371/journal.pone.0124994 91 JungY.LippardS

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However, disadvantages and risks include insertional mutagenesis from viral vectors, increasing the risk of leukemia or clonal expansion, and off-target effects from CRISPR editing, leading to unintended mutations

References Rosenberg, H
