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It was shown that this cascade does not act on a widespread cell level but that it mainly regulates molecular events at specific synapses, e.g

[DOI] [PubMed] [Google Scholar] Esipov R., Stepanenko V., Chupova L., Boyarskikh U., Filipenko M., Miroshnikov A

Front Vet Sci 2018

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For something to pass directly into the bloodstream, it has to be tiny (were talking nanoparticles) and neutral (neither positively nor negatively charged)

However, under conditions of overexpression, gene mutation, and Serine 129 phosphorylation, -syn aggregates abnormally and eventually forms neurotoxic oligomers, fibrils, and Lewy bodies [206, 207]