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Also supporting the hypothesis of involvement of an oxidant stress in hyperhomocysteinemia-mediated vascular disorders, an increase in plasma and aortic thiobarbituric acid reactive substances was related to the occurrence of atherosclerotic lesions in animals fed a methionine-enriched diet (Matthias et al, 1996

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We found that GCLC knockout significantly increased Pt-DNA adduct formation, which was blocked by the addition of exogenous glutathione (Fig

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