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The coq oxidoreductase fsp1 acts parallel to gpx4 to inhibit ferroptosis

Investigators tapered or paused doses if intolerance developed (57.4% maintained maximum dose at week 68

Safety, Tolerability, and Regulatory Perspective Multiple non-clinical toxicology programs and clinical studies have evaluated the safety of AOD 9604: A comprehensive non-clinical dossier reported no evidence of genotoxicity or major toxicological concerns across a range of pharmacokinetic and toxicity studies, supporting a favorable safety profile in standard preclinical models

Siller et al., 2015

J Clin Endocrinol Metab 75 : 11861191 Louard RJ et al

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