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Prevalence of polyneuropathy in pre-diabetes and diabetes is associated with abdominal obesity and macroangiopathy: the MONICA/KORA Augsburg Surveys S2 and S3

One notable example of drug development pipelines influenced by preclinical findings include the advancement of elamipretide, a peptide designed to stabilize mitochondrial membranes, which showed efficacy in preclinical models of Barth syndrome and Primary Mitochondrial Myopathy and subsequently progressed to clinical trials (Sabbah, 2022

Lutz PE, Tanti A, Gasecka A, Barnett-Burns S, Kim JJ, Zhou Y, et al

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A long (20 h) exposure to hypoxia significantly increased Hba and Hbb expression and raised the levels of tetrameric hemoglobin in murine MLE-15 cells (161)