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Variants in the CaSR (calcium-sensing receptor) gene increase the risk of kidney stones due to the association between calcium binding to oxalate to form stones

This is known as steady state and the steady state concentration (C ss ) depends solely on the balance between the infusion rate (IR) and the clearance rate (Cl), as follows: This relationship means that if a measured steady state concentration is too low or too high, a new dose can be determined by direct proportion

The peptide was cleaved from the 4.53 g peptide resin by treatment with 54 ml TFA/phenol/ethanedithiol/thioanisole/water 40:3:1:2:2 for 3 h at room temperature

In contrast, other cases of bioactivation may lead to the production of harmful metabolites that result in toxicity or side effects

& Baier, G