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The cycle structure exists for a practical reason: continuous stimulation of the same receptor pathways can lead to reduced sensitivity over time, and a rest period allows the system to reset before the next cycle produces full effect

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Pre-clinical assessment of SAR442257, a CD38/CD3xCD28 trispecific T cell engager in treatment of relapsed/refractory multiple myeloma

For research use only : Not intended for human or animal use

The metabolic support process develops progressively over weeks to months, with optimal results requiring consistent administration alongside proper nutrition and exercise

DeGregori, J