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When the substrate is a drug, these reactions usually convert the original drug to a form that is not able to bind to its target receptor, thus attenuating the biological response to the drug

Within the acidic environment of endosomes, Fe 3+ is released from TF and reduced to Fe 2+ by metalloreductases such as STEAP3 (Zhang et al., 2012)

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The imidazole ring sidechain of H220 rotates in an anti-clockwise direction and thus does not get involved in bond formation

Saposin C mutations in gaucher disease patients resulting in lysosomal lipid accumulation, saposin c deficiency, but normal prosaposin processing and sorting