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In 2015, Gur et al
This synergy is thought to result from complementary intracellular signalling mechanisms GHRH receptor activation increases cAMP via Gs coupling, while ghrelin receptor activation increases intracellular calcium and activates protein kinase C via Gq/11 coupling
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doi: 10.1007/s40199-019-00283-2
In contrast to older GHS peptides, it doesnt have much of an effect on appetite (no raging hunger spikes)
Available from: 134.Ackland ML, Michalczyk A
