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Three times daily systemic (SC) treatment of DIO mice with 20 mg/kg of 5-amino-1MQ produced a progressive loss of body weight over the treatment period compared to controls (Figure 5A)

It is important to distinguish between excessive supplementation and pathologically elevated B12 levels, which may indicate underlying haematological disorders, liver disease, or renal impairment rather than true overdose

Even injecting a whole vial of 15,000g of B12 at once cant do you any harm

For cat growth, breeding, and adult maintenance, the American Association of Feed Control Officials (AAFCO) recommends a dietary cobalamin intake of 4.5 g per 1000 Kcal ME [11]

Liver issues can also affect how B12 is used and stored

If there is a lack of B12 in your system, it can lead to nerve damage