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These epigenetic modifications affect the physiological behaviors, including PCD inhibition, metabolic reprogramming, the formation and maintenance of drug-resistant cells, cell proliferation signaling pathway dysregulation, and abnormal HCC transport process, ultimately leading to resistance to sorafenib and lenvatinib
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doi: 10.1016/j.pbb.2005.01.029, 90
65% of clinicians currently considered ALP of equal importance as alterations of PTH as a predictor of fracture events
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