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J Neurosci 25 : 19791984

11 The antecedent Selyes organoprotective issue, the damage consequent to acute nonspecific nocuous agents that produce the organism severely damaged in rat experiments, 22 since the very beginning, clearly indicated what should be the essential proof of concept and interposed agent activity supposed to be involved in the counteractive coping response organization

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In a first-in-human clinical study in healthy volunteers, AMG 966 elicited anti-drug antibodies (ADA) in 53 of 54 subjects (98.1%), despite a paucity of T cell epitopes observed in T cell assays
