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The National Institute of Health (NIH) shares that the recommended dietary allowance (RDA) for vitamin B12 is: Infants 06 months: 0.4 microgram Infants 712 months: 0.5 microgram Toddlers 13 years: 0.9 microgram Children 48 years: 1.2 micrograms Children 913 years: 1.8 micrograms Adult men and women over age 14: 2.4 micrograms Women who are pregnant: 2.6 micrograms Women who are breastfeeding: 2.8micrograms For adults over 50 years old, the NIH recommends taking a daily vitamin B12 supplement or consuming foods fortified with vitamin B12

NNMT is overexpressed in white adipose tissue in obese individuals, where it consumes S-adenosylmethionine (SAM) the body's primary methyl donor to methylate nicotinamide, effectively draining the methyl pool and reducing NAD+ precursor availability