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Zerimech, S., Nguyen, H., Vandenbark, A

majority of TBI and stroke studies Mice Used for transgenic Alzheimers models (APP, APP/PS1) and excitotoxicity studies Humans Multiple clinical trials in stroke, dementia, and TBI populations Cell culture Cortical neurons, hippocampal cultures, endothelial cells for mechanistic studies Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite over 1,000 preclinical studies and numerous clinical trials, Cerebrolysin faces substantial translational challenges that significantly limit its therapeutic utility

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PMID: 29155147 View source Kraus D, et al

So it is restricted to a finite water volume within the body

2023 Aug 26;402(10403):720-730