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Nature 613 , 160168 (2023)
By inhibiting HMG-CoA reductase, statins reduce the hepatocyte cholesterol content, stimulate the expression of LDLR, and ultimately enhance removal of LDL-C from the circulation ( Most LDL-Ps are cleared by LDLR that located at the surface of hepatocytes
There was a history of fever 5 days before the lesions appeared
A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis
