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MTHFD2 is overexpressed in cancers [116]

Imura, Y., Nishida, M., Ogawa, Y., Takakura, Y

By supporting electron transport chain activity, Methylene Blue may improve mitochondrial efficiency and cognitive energy production

Preclinical research demonstrates that small molecules or stabilized peptide fragments may be absorbed through these tissues, though variability in saliva, pH, and mucosal permeability affects systemic exposure

oxidative haemolysis Precipitants of oxidative haemolysis Drugs Dapsone, Co-trimoxazole, Rasburicase, Sulfasalazine, Antimalarials, Chloramphenicol, Methylene blue, Quinolones, Nitrofurantoin (Aspirin, Quinine and Pencillin but not at conventional doses) Food Fava beans (contain oxidising agents divicine and isouramil) Infection Hep A, Hep B, CMV, Pneumonia & Typhoid are known triggers of haemolysis in G6PD deficient patients Other acute illness e.g

The presence of PGP at the peptides C-terminus might alter how it interacts with certain transporters or receptors on the blood-brain barrier
