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Wells G, Shea B, OConnell D et al (2004) The NewcastleOttawa Scale (NOQAS) for assessing the quality of non-randomized studies in meta-analysis
Additionally, sterile water is hypotonic (lower solute concentration than many biological fluids), which may affect certain laboratory experiments if used improperly without buffering or proper formulation
Management generally involves levothyroxine replacement therapy, complemented in some cases by dietary optimization and micronutrient supplementation
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