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doi: 10.1038/s41467-024-45675-4 107 WalkeGGaurkarSSPrasadRLohakareTWanjariM

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Beyond its detoxifying role, GST also participates in multiple biological processes such as cell signaling, post-translational modification, and programmed cell senescence

When that balance is strained, tissues may feel more reactive and less resilient

Though the profile of amoxicillin does not meet all our criteria for rectal absorption, given its relatively low molecular weight and pKa near neutral, it is not surprising that rectal bioavailability is such that dosing via this route could be possible

10.1038/s41586-019-1705-2 5 BhatM