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ROS may further decrease ATP levels, because glutathione and NADPH are required for the detoxification of ROS in the mitochondria and mitochondrial proton gradient is required to drive the transhydrogenase to reduce NADP+ (by NADH) to form NADPH [94]

Propofol was also found to impair the mitochondrial ETC in isolated heart samples from guinea pigs [132]

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TMAO causes vascular dysfunction and hypertension, two important risk factors for ischemic stroke [77]

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Since the body does not store large amounts of water-soluble vitamins, maintaining their potency is important for consistent nutrient intake