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Notably, amyloid deposits in ATTR patients correlate with markers of lipid peroxidation, such as 4hydroxytrans2nonenal (HNE) adducts [35] and oxidative DNA damage indicated by 8hydroxy2deoxyguanosine (8OhdG) [34]

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The ligandreceptor interaction results in phosphorylation of tyrosine residues in the IGF-1R TK domain (spanning amino acid 9731229) of the -subunit

N-acetylcysteine (NAC) is a cysteine prodrug and glutamate modulator that promotes homeostatic regulation of glutamate by astrocytes [8]
doi: 10.1186/s12933-025-02614-x 14 WenJLiLYangYOuDYangJXieJet al
