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The reason this pressure decreases is because the dural sac that encases the spinal cord becomes punctured, creating a hole that the fluid can leak out of

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Among these targets, 71 were associated with A, Tau, A, and Tau (Figure 11A), specifically, PIK3CD, CDC42, PDE4D, HTR4, ADRA1B, ARG1, PTGS1, PRF1, ADRA2A, CD81, CRYAB, BACE1, CDK2, MDM2, ALDH2, CYP19A1, NOS2, CSNK1D, PRKACA, CSNK2A1, PLCG1, CBS, and MIF were significantly associated with A pathology, EPHB2, LCK, JUN, ZAP70, DPP4, HTR2B, MAPK10, HTR1A, VEGFA, HTR1B, CFTR, CHRM2, GBA2, GSTP1, MMP3, HTR3A, CD4, VDR, MAPK3, and CHEK2 were significantly associated with Tau pathology

The main safety concern is cancer