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Codeine and other opioid-based painkillers both slow gut motility, as does semaglutide

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These mechanisms act on cardiomyocytes and the coronary microvascular system, ultimately leading to diastolic dysfunction and ventricular stiffness

doi: 10.3389/fendo.2019.00492 84 VniantMMLuS-CAtanganLKomorowskiRStanislausSChengYet al

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This is why a one size fits all approach often fails