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Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance

by the Core Center for iPS Cell Research of Research Center Network for Realization of Regenerative Medicine [JP21bm0104001] from the Japan Agency for Medical Research and Development (AMED) and the Acceleration Program for Intractable Diseases Research utilizing Disease-specific iPS cells from AMED [17935423], and to Y.K

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A differential metabolomics study suggests that the depletion of glutathione after low dose APAP (150mg/kg) is paralleled by elevation in the glutathione analogue ophthalmic acid, where the SH group of the cysteine residue of GSH is replaced with a CH3 group from 2-aminobutyrate [21]