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Basic & Clinical Pharmacology

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Biased leptin analogs decouple activation of STAT3 from LepR negative regulators The leptin-mediated dimerization of LepR results in the JAK2-dependent phosphorylation of multiple tyrosine residues on the intracellular domain (ICD) of LepR, each of which have distinct biological roles 5,13

[DOI] [PMC free article] [PubMed] [Google Scholar] 160.Hester JM, Wing MR, Li J, Palmer ND, Xu J, Hicks PJ, Roh BH, Norris JM, Wagenknecht LE, Langefeld CD, Freedman BI, Bowden DW, Ng MC

The HPI axis is the primary neuroendocrine system that mediates the stress response in fish