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This leads to the subsequent excessive release of ER calcium into the cytoplasm

Furthermore, a significant reduction in proteasome-mediated degradation of oxidized proteins in brains from MCI and AD subjects was associated with the increase of ox-PTMs such as carbonylation, HNE modification, and neuroprostane conjugation, thereby confirming a role for OS as a contributing factor (354)

The defect in ATP generation is unlikely to be the sole cause, as ATP deficiency is difficult to demonstrate in many patients and other disorders with more severe ATP deficiency are not associated with significant hemolysis

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doi:10.1186/1475-2891-9-55 di Tomaso E, Beltramo M, Piomelli D