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FIGURE 5 Conclusion In summary, we demonstrate that both the GF and SM protocols generate iPSC-HLCs with definitive hepatic phenotype

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The demonstrated importance of protecting the terminals to pharmacokinetic characteristics suggests numerous additional synthetic approaches that may be applicable including the insertion of non-peptide linkages between the first and second amino acids, the replacement of the N~terminal amino acid with a non-a amino acid, and N-terminal acylation