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Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications

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The most often and potent ones attracted are the insulin receptor substrates 1/2 (IRS1/2)although there are 6 found to date- (not to forget that Shc proteins, p60dok, Cbl, APS, and Gab-1 are also recruited to activated IRs)

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Notably, PC-3M (prostate cancer cell lines) subpopulations with stem-like features exhibit heightened glutamine dependency characterized by elevated GLS1 expression and enhanced reductive carboxylation activity, forming a bidirectional regulatory loop between glutamine metabolism and epigenetic reprogramming (44)

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