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Upon activation by TGF-, Smad proteins are phosphorylated and translocate into the nucleus, where they initiate specific transcriptional activities that regulate the expression of genes involved in the fibrotic process ( Figure 2 Connective tissue growth factor (CTGF/CCN2) expression, which is regulated by TGF- signaling, is another significant player in the fibrotic pathway ( 3.2.2 Interaction of TGF- with other signaling pathways in fibrotic progression In the intricate landscape of fibrosis, the interplay between TGF- and key signaling pathways such as Wnt/-catenin, MAPK, and PI3K/Akt is crucial

Science 241 : 4252 Johnson LN, Noble ME and Owen DJ (1996) Active and inactive protein kinases: structural basis for regulation