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The landmark PANTHEON trial, a 1-year multicenter RCT in 1,006 Chinese COPD patients, found that high-dose NAC (600 mg twice daily) reduced the rate of acute exacerbations by 22% compared to placebo (1.16 vs 1.49 exacerbations per year, p=0.0011) (Zheng et al., Lancet Respir Med, 2014) [44]

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NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth

doi: 10.1016/j.ijpx.2021.100087 163

Moreover, they identified three cases of pediatric B-ALL with mLH, two with TP53 mutations and one untested [360]

9 Elevated GSH, a product of glycolysis and the citric acid cycle, as a result of KD, was demonstrated in a rat model of Parkinson's disease compared to controls, validating the idea that ketone bodies may influence GSH concentration