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Cigarette smoke, biomass smoke, and air pollution sources cause prolonged inflammation of the lung, and they cause activation of alveolar macrophages and neutrophils, resulting in the production of increased free radicals and pro-inflammatory cytokines

Maddalena, G, van der Pol, Y, Rivers, Z, Dasari, NV, Rogers, JE, Guinney, J, Kopetz, S , Raghav, KS

reported that 4-HNE participates in p53-mediated signaling by phosphorylating p53, inducing activation and nuclear aggregation and leading to apoptosis (43)

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Cortese et al., 2020)

The gating strategy for C 12 FDG-Annexin V-7AAD flow cytometry was shown in Supplementary Fig