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In contrast, novel matrices exhibit remarkable characteristics, including enhanced analyte ionization efficiency and sensitivity, increased MW to reduce matrix ion interference, reduced volatility of small molecules, and improved ability to analyze compound structures by MALDI-MS

Warburg first observed that cancer cells have an increased demand for glucose and increased glycolysis compared to non-cancer cells (Warburg et al., 1927)

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These cytokines also downregulate antigen presentation and impair the recruitment and activation of effector T cells (144)

Furthermore, the concentration of ApoE secreted was identical between apoE3 and apoE4 macrophages (16)

447 Additionally, engineering GBM cells to express miR-302 and miR-367 profoundly affects the surrounding tumor environment, leading to decreased proliferation, reduced tumorigenicity, and the modulation of stemness markers in neighboring GBM cells