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PATHOPHYSIOLOGY The syndrome is a complex, multifactorial disorder of the brain-gut axis of as yet unclear pathogenesis, often associated with other episodic conditions like migraine headaches and abdominal migraine [9]

Suppression of inflammatory arthritis by human gut-derived Prevotella histicola in humanized mice

Ingestion of hyaluronans (molecular weights 800 k and 300 k) improves dry skin conditions: a randomized, double blind, controlled study

doi: 10.1016/j.cell.2012.03.042 4 TangDKangRBergheTVVandenabeelePKroemerG

It needs to soak in, not disturb the skin surface