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GSHGSSG redox cycle The reversible conversion between glutathione (GSH) and its oxidized form, glutathione disulfide (GSSG), constitutes one of the most core cellular redox buffering systems

When used at standard dosing (2 mg daily), most adverse events are mild and manageable

However, distinctively compared to other polyphenols, curcumin stands out as the most extensively studied component in clinical trials and human studies

The target genes for the antioxidant response encode a set of enzymes and other proteins that scavenge free radicals, neutralise electrophiles or up-regulate the critical cellular thiol, glutathione

[DOI] [PubMed] [Google Scholar] 14.Green R