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Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial

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Studies have established links between oral diseases, especially periodontitis, and various systemic diseases, including cardiovascular diseases (CVD) ( Dental plaque is the primary cause of oral diseases ( Streptococcus mutans ( Sm ) are the initial inhabitants of dental plaque, adhering through mechanisms mediated by RadD and other mechanisms ( Fusobacterium nucleatum ( Fn ), it promotes adhesion by recognizing and binding to partner adhesins on other species, such as SpaP on Sm , as demonstrated in heterologous expression systems ( Fn plays a central bridging role in the formation of oral biofilms, uniquely positioned to interact with both early and late colonizers such as Sm and Porphyromonas gingivalis ( Pg ) in the oral cavity ( Pg are subsequently incorporated into the biofilm through adhesins such as Fap2, thereby exacerbating oral diseases ( Research has demonstrated that the progression of systemic disease is significantly influenced by gut microbiota and their metabolites through the intestinal pathway ( in vitro involves members of the genera Anaerococcus , Clostridium , Escherichia , Proteus , Providencia , and Edwardsiella ( Studies now show a marked correlation between TMAO levels and CVD ( Recently, studies highlighted a potential association between oral diseases and TMAO